PUblications

EMTHERA Faculty members are very actively publishing in peer-reviewed, high-ranking journals. Below is a selection of 25 publications since 2018 which gives a flavour of the interdisciplinarity and the ambitious questions tackled.

Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. 2018; 19(12): 1319-1329. doi: 10.1038/s41590-018-0226-8.

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Muench C. SARS-CoV-2 infected host cell proteomics reveal potential therapy targets. Nature. 2020; 583 (7816): 469-472. doi: 10.1038/s41586-020-2332-7.

Broft P, Dzatko S, Krafcikova M, Wacker A, Hänsel-Hertsch R, Dötsch V, Trantirek L, Schwalbe H. In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells. Angew Chem Int Ed Engl. 2021; 60(2): 865-872. doi: 10.1002/anie.202007184.

de Vries C, Galipaud M, Kokko H. Extrinsic mortality and senescence: a guide for the perplexed. Peer Community Journal. 2023; 3: e29. doi: 10.24072/pcjournal.253.

Ellinger B, Bojkova D*, Zaliani A, Cinatl J, Claussen C, Westhaus S, Keminer O, Reinshagen J, Kuzikov M, Wolf M, Geisslinger G, Gribbon P, Ciesek S. A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection. Sci Data. 2021; 8(1): 70. doi: 10.1038/s41597-021-00848-4.

Flinner N, Gretser S*, Quaas A, Bankov K, Stoll A, Heckmann LE, Mayer RS, Doering C, Demes MC, Buettner R, Rueschoff J, Wild PJ. Deep learning based on hematoxylin-eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma. J Pathol. 2022; 257(2): 218-226. doi: 10.1002/path.5879.

​

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA. Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature. 2023 Jun;618(7964):402-410. doi: 10.1038/s41586-023-06090-9. 

​

González A, Covarrubias-Pinto, A, Bhaskara, RM, Glogger, M, Kuncha, SK, Xavier, A, Seemann, E, Misra, M, Hoffmann, ME, Bräuning, B, Balakrishnan, A, Qualmann, B, Dötsch, V, Schulman, BA, Kessels, MM, Hübner, CA, Heilemann, M, Hummer G, Dikic I. Ubiquitination regulates ER-phagy and remodeling of the endoplasmic reticulum. Nature. 2023. doi: 10.1038/s41586-023-06089-2.

Gonçalves JP, Promlok D, Ivanov T, Tao S, Rheinberger T, Jo SM, Yu Y, Graf R, Wagner M, Crespy D, Wurm FR, Caire da Silva L, Jiang S, Landfester K. Confining the Sol-Gel Reaction at the Water/Oil Interface: Creating Compartmentalized Enzymatic Nano-Organelles for Artificial Cells. Angew Chem Int Ed Engl. 2023; 62(11): e202216966. doi: 10.1002/anie.202216966.

Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D. Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation. EMBO J. 2022; 41(8): e108443. doi: 10.15252/embj.2021108443.

Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D, Behrens P, Böddinghaus B, Götsch U, Naujoks F, Neumann P, Schork J, Tiarks-Jungk P, Walczok A, Eickmann M, Vehreschild MJGT, Kann G, Wolf T, Gottschalk R, Ciesek S. Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China. N Engl J Med. 2020; 382(13): 1278-1280. doi: 10.1056/NEJMc2001899.

Kielholz T, Rohde F, Jung N, Windbergs M. Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections. Sci Rep. 2023. doi: 10.1038/s41598-023-35364-5.

Krienke C, Kolb L, Diken E*, Streuber M, Kirchhoff S, Bukur T, Akilli-Öztürk Ö, Kranz LM, Berger H, Petschenka J, Diken M, Kreiter S, Yogev N, Waisman A, Karikó K, Türeci Ö, Sahin U. A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis. Science. 2021; 371(6525): 145-153. doi: 10.1126/science.aay3638.

Larochelle C, Wasser B, Jamann H, Löffel JT, Cui QL, Tastet O, Schillner M, Luchtman D, Birkenstock J, Stroh A, Antel J, Bittner S*, Zipp F. Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation. Proc Natl Acad Sci U S A. 2021; 118(34): e2025813118. doi: 10.1073/pnas.2025813118.

Luck K, Kim DK, Lambourne L, Spirohn K, et int, Hill DE#, Vidal M, Roth FP, Calderwood MA. A reference map of the human binary protein interactome. Nature. 2020; 580(7803): 402-408. doi: 10.1038/s41586-020-2188-x.

Mosalaganti S, Obarska-Kosinska A, Siggel M, Taniguchi R, Turoňová B, Zimmerli CE, Buczak K, Schmidt FH, Margiotta E, Mackmull MT, Hagen WJH, Hummer G, Kosinski J, Beck M. AI-based structure prediction empowers integrative structural analysis of human nuclear pores. Science. 2022; 376(6598): eabm9506. doi: 10.1126/science.abm9506.

Muik A, Lui BG, Wallisch AK, Bacher M, Mühl J, Reinholz J, Ozhelvaci O, Beckmann N, Güimil Garcia RC, Poran A, Shpyro S, Finlayson A, Cai H, Yang Q, Swanson KA, Türeci Ö, Şahin U. Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera. Science. 2022; 375(6581): 678-680. doi: 10.1126/science.abn7591.

Müller-Calleja N, Hollerbach A, Royce J, Ritter S, Pedrosa D, Madhusudhan T, Teifel S, Meineck M, Häuser F, Canisius A, Nguyen TS, Braun J, Bruns K, Etzold A, Zechner U, Strand S, Radsak M, Strand D, Gu JM, Weinmann-Menke J, Esmon CT, Teyton L, Lackner KJ, Ruf W. Lipid presentation by the protein C receptor links coagulation with autoimmunity. Science. 2021; 371(6534): eabc0956. doi: 10.1126/science.abc0956.

Reinkemeier CD, Lemke EA. Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation. Cell. 2021; 184(19): 4886-4903.e21. doi: 10.1016/j.cell.2021.08.001.

Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, Baum A, Pascal K, Quandt J, Maurus D, Brachtendorf S, Lörks V, Sikorski J, Hilker R, Becker D, Eller AK, Grützner J, Boesler C, Rosenbaum C, Kühnle MC, Luxemburger U, Kemmer-Brück A, Langer D, Bexon M, Bolte S, Karikó K, Palanche T, Fischer B, Schultz A, Shi PY, Fontes-Garfias C, Perez JL, Swanson KA, Loschko J, Scully IL, Cutler M, Kalina W, Kyratsous CA, Cooper D, Dormitzer PR, Jansen KU, Türeci Ö. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Nature. 2020; 586(7830): 594-599. doi: 10.1038/s41586-020-2814-7.

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 2020; 587(7835): 657-662. doi: 10.1038/s41586-020-2601-5.

​

Sutandy FXR, Gößner I, Tascher G, Münch C. A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature. 2023 Jun;618(7966):849-854. doi: 10.1038/s41586-023-06142-0.

​

Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS. Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood. 2019; 134(3): 227-238. doi: 10.1182/blood.2018874214.

Vieira-Silva S, Falony G, Belda E, et int, Clément K, Raes J. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature. 2020; 581(7808): 310-315. doi: 10.1038/s41586-020-2269-x.

Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M. Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes. Nucleic Acids Res. 2020; 48(7): 3734-3746. doi: 10.1093/nar/gkaa113.

Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH#, Müller S, Fedorov O, Filippakopoulos P, Knapp S. A chemical toolbox for the study of bromodomains and epigenetic signaling. Nat Commun. 2019; 10(1): 1915. doi: 10.1038/s41467-019-09672-2.

Yu M, Heidari M, Mikhaleva S, Tan PS, Mingu S, Ruan H, Reinkemeier CD, A Obarska-Kosinska, Siggel M, Beck M, Hummer G, Lemke EA. Visualising the disordered nuclear transport machinery in situ. Nature 2023; 617(7959):162-169. doi: 10.1038/s41586-023-05990-0.

​